Farnesol , an isoprenoid , improves metabolic abnormalities in mice via both 1 PPAR α - dependent and - independent pathways
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چکیده
Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both 1 PPARα-dependent and -independent pathways 2 3 Tsuyoshi Goto 1, , Young-Il Kim , Kozue Funakoshi , Aki Teraminami , Taku Uemura , 4 Shizuka Hirai , Joo-Young Lee , Makoto Makishima , Rieko Nakata , Hiroyasu Inoue , 5 Hiroyuki Senju , Masayoshi Matsunaga , Fumihiko Horio , Nobuyuki Takahashi 1, , and 6 Teruo Kawada 1,2, § 7 8 1 Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, 9 Graduate School of Agriculture, Kyoto University, Uji 611-0011, Japan 10 2 Research Unit for Physiological Chemistry, the Center for the Promotion of Interdisciplinary 11 Education and Research, Kyoto University, Japan 12 3 Department of Biochemistry, Nihon University School of Medicine, Itabashi-ku, Tokyo 13 173-8610, Japan 14 4 Department of Food Science and Nutrition, Nara Women's University, Nara 630-8506, Japan 15 5 Hakutsuru Sake Brewing Co., Kobe 658-0041 Japan 16 6 Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, 17 Nagoya University, Nagoya 464-8601, Japan 18 19 § Corresponding Author: Teruo Kawada, Ph.D. 20 Laboratory of Molecular Function of Food, Division of Food Science 21 and Biotechnology, Graduate School of Agriculture, Kyoto University 22 Uji 611-0011, Japan 23 TEL: +81-774-38-3751 24 Articles in PresS. Am J Physiol Endocrinol Metab (August 23, 2011). doi:10.1152/ajpendo.00061.2011
منابع مشابه
Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.
Peroxisome proliferator-activated receptors (PPARs) control energy homeostasis. In this study, we showed that farnesol, a naturally occurring ligand of PPARs, could ameliorate metabolic diseases. Obese KK-Ay mice fed a high-fat diet (HFD) containing 0.5% farnesol showed significantly decreased serum glucose level, glucosuria incidence, and hepatic triglyceride contents. Farnesol-containing HFD ...
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